Upper Reference Limits for High-Sensitivity Cardiac Troponin T and N-Terminal Fragment of the Prohormone Brain Natriuretic Peptide in Patients With CKD
In: American Journal of Kidney Diseases, Jg. 79 (2022-03-01), S. 383-392
Online
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Zugriff:
RATIONALE & OBJECTIVE: The utility of conventional upper reference limits (URL) for N-terminal pro brain natriuretic peptide (NT-proBNP) and high-sensitivity cardiac troponin T (hsTnT) in chronic kidney disease (CKD) remains debated. We analyzed the distribution of hsTnT and NT-proBNP in people with CKD in ambulatory settings to examine the diagnostic value of conventional URL in this population. STUDY DESIGN: Observational study. SETTING & PARTICIPANTS: We studied participants of the Chronic Renal Insufficiency Cohort with CKD and no self-reported history of cardiovascular disease (CVD). EXPOSURE: Estimated glomerular filtration rate (eGFR). OUTCOMES: NT-proBNP and hsTnT at baseline. ANALYTICAL APPROACH:. We described the proportion of participants above the conventional URL for NT-proBNP (125 pg/ml) and hsTnT (14 ng/L) overall, and by eGFR. We then estimated 99(th) percentile URL for NT-proBNP and hsTnT. Using quantile regression of the 99(th) percentile, we modeled the association of eGFR with NT-proBNP and hsTnT. RESULTS: Among 2,312 CKD participants, 40% and 43% had levels of NT-proBNP and hsTnT above conventional URL, respectively. In those with eGFR
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Upper Reference Limits for High-Sensitivity Cardiac Troponin T and N-Terminal Fragment of the Prohormone Brain Natriuretic Peptide in Patients With CKD
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Autor/in / Beteiligte Person: | Bansal, Nisha ; Zelnick, Leila R. ; Ballantyne, Christie M. ; Paulo H.M. Chaves ; Christenson, Robert H. ; Coresh, Josef ; deFilippi, Christopher R. ; James A. de Lemos ; Daniels, Lori B. ; Go, Alan S. ; He, Jiang ; S. Susan Hedayati ; Matsushita, Kunihiro ; Nambi, Vijay ; Shlipak, Michael G. ; Taliercio, Jonathan J. ; Seliger, Stephen L. ; Appel, Lawrence J. ; Feldman, Harold I. ; Lash, James P. ; Nelson, Robert G. ; Rao, Panduranga S. ; Rahman, Mahboob ; Shah, Vallabh O. ; Townsend, Raymond R. ; Unruh, Mark L. |
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Zeitschrift: | American Journal of Kidney Diseases, Jg. 79 (2022-03-01), S. 383-392 |
Veröffentlichung: | Elsevier BV, 2022 |
Medientyp: | unknown |
ISSN: | 0272-6386 (print) |
DOI: | 10.1053/j.ajkd.2021.06.017 |
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